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Fucom
Lincomycin Hydrochloride Injection
Main Ingredient
Lincomycin Hydrochloride

Characteristic
Colorless to yellowish or yellowish-green clear liquid.

Pharmacological Action
Pharmacodynamics Lincomycin, a bacteriostatic agents, belongs to of Lincosamide antibiotics. Its sensitive bacteria includes Staphylococcus aureus (including penicillin-resistant strains), Streptococcus, pneumococcus, Bacillus anthracis, Erysipelas, mycoplasma (pig pneumonia Mycoplasma, Mycoplasma hyorhinis, Mycoplasma hyalinocystis), Leptospira and anaerobes (such as Fusobacterium, Clostridium tetani, Clostridium perfringens and most actinomycetes, etc.). Mainly acting on the 50S subunit of bacterial ribosomes and exerting antibacterial action by inhibiting the extension of peptide chain and affecting protein synthesis.
Pharmacokinetics Absorbed rapidly by intramuscular injection, single intramuscular injection of 11mg / kg, peak plasma concentration of 6.25μg / ml. Plasma protein binding rate of 57% to 72%. Wide distribution in vivo, the apparent distribution volume in pigs was 2.8 L/kg. Widely distributed to a variety of body fluids, tissues (including bones), and the concentration in liver and kidney is the highest, tissue drug concentration several times higher than the same period serum concentration. Can enter the placenta, but not easily through the blood-brain barrier, and it also difficult to achieve effective concentration in the cerebrospinal fluid when it has inflammation. Can be distributed to milk, and the drug concentration is the same as plasma. Part of the drug metabolism in the liver, drug prototype and its metabolites excreted by bile, urine and milk. Fecal excretion can be delayed for several days, so it has inhibitory effect on intestinal microbial.

Drug Interaction
1) When combined with gentamicin, Staphylococcus, Streptococcus and other Gram-positive bacteria, it has synergistic effect.
2) When combined with aminoglycosides and peptide antibiotics, the nerve-muscle joint block effect may be enhanced. And there is antagonism when combined with erythromycin, due to the same site of action, and affinity of erythromycin to bacterial ribosomal 50S subunit is stronger than this product.
3) Should not combine with the antidiarrheal which inhibit intestinal peristalsis and with white clay.

Indication
For the treatment of gram-positive bacterial infection, can also be used for swine leptospirosis and Mycoplasma infection, etc.

Usage & Dosage
Intramuscular injection: 0.033ml/ kg body weight for pig, once a day; 0.033ml for dogs, cats, twice a day, used for 3 ~ 5 days.

Adverse Reaction
With neuromuscular blocking effect.

Precaution
Intramuscular injection may cause transient diarrhea or loose stools. If necessary, take appropriate measures to prevent dehydration.

Withdrawal Period
2 days for pigs.

Specification
100ml∶30g  C18H34N2O6S 

Storage
Keep in tightly closed container.